Table 3 Univariate and multivariate analysis of the association of prognosis with clinicopathologic parameters and SPOCK1 expression in GBC patients
Variable | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Age (<60 vs. ≥60) | 0.502 (0.240-1.051) | 0.062 | - | - |
Sex (male vs. female) | 1.076 (0.575-2.017) | 0.818 | - | - |
Jaundice (present vs. absent) | 1.324 (0.780-2.409) | 0.356 | - | - |
Associated gallstone (present vs. absent) | 0.550 (0.294-1.030) | 0.058 | - | - |
Histology differentiation (well or moderate vs. poor) | 0.431 (0.233-0.796) | 0.006 | 1.480 (0.721-3.038) | 0.286 |
Tumor invasion (AJCC) (Tis-T1 vs. T2-T4) | 6.272 (2.507-15.691) | <0.001 | 8.136 (2.584-25.619) | <0.001 |
Lymph node metastasis (present vs. absent) | 6.278 (3.126-12.611) | <0.001 | 2.653 (1.100-6.396) | 0.030 |
TNM stage (AJCC) (0-I vs. II-IV) | 6.272 (2.507-15.691) | <0.001 | 8.136 (2.584-25.619) | <0.001 |
Type of surgery (curative resection vs. palliative) | 0.687 (0.361-1.307) | 0.249 | - | - |
Overexpression of SPOCK1 in tumor | Â | Â | Â | Â |
(Negative vs. positive) | 0.346 (0.181-0.659) | 0.001 | 0.378 (0.164-0.871) | 0.022 |