Figure 4From: miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia MiR-17 deregulates a core RUNX1-miRNA mechanism of CBF-AML pathogenesis. Scheme showing that miR-17 and the RUNX1-MTG8 and CBFB-MYH11 fusion proteins interfere with the same core RUNX1-miRNA mechanism that regulates KIT-mediated proliferation and myeloid differentiation. MiR-17 and the two fusion proteins are expected to produce distinct phenotypes, which may explain their association with different leukemia FAB subtypes. Other miRNAs targeting RUNX1-3′UTR could also affect the RUNX1-miRNA core mechanism.Back to article page