Figure 7
From: miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia
Inhibition of KIT activity counteracts the delay effect on myeloid differentiation due to KIT overexpression. (A) Imatinib (1 μM) significantly decreases the proliferation of 32DKIT-High cells during G-CSF-induced differentiation, while it does not affect control 32DEV cells. (B) CD11b cytofluorimetric analysis at different time points during G-CSF-induced differentiation showing that the KIT-induced delay of myeloid differentiation in 32DKIT-High cells is counteracted by imatinib. See Additional file 4: Table S3 for statistical significance.