Figure 6From: Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes Working hypothesis of KLF4 function in T-ALL. KLF4 induces apoptosis in T-ALL cells by directly suppressing BCL2 by directly suppressing NOTCH1 transcription and inducing BCL11B degradation.Back to article page