Figure 4

Network graph showing interactions between ID2 and ID3 and their MIC-inferred ‘target’ genes regulating cell death. MIC-inferred apoptosis target genes, denoted by green nodes connected to ID2/ID3 by blue edges, were compiled from apoptosis pathway target genes in Additional file 6: Table S4. Green edges define protein-protein interactions, curated from the String database [28]. Pink edges denote literature-validated regulatory interactions mined from the UniHI database [29] that have been expanded to include first-neighbour interactions with additional targets as either pink nodes (not MIC-inferred target genes) or as grey (ID3) or white (ID2) MIC-inferred target genes listed in Additional file 5: Table S3. A Cytoscape network graph circle layout is shown.