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Figure 7 | Molecular Cancer

Figure 7

From: Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor

Figure 7

PTN and VEGF compete for binding to RPTPβ/ζ. (A) Formation of VEGF-RPTPβ/ζ complexes as evidenced by in situ PLA in HUVEC in the absence or the presence of exogenous PTN (100 ng/ml). (Β) Formation of PTN-RPTPβ/ζ complexes as evidenced by in situ PLA in HUVEC in the absence or the presence of exogenous VEGF165 (10 ng/ml). The box plots in A and B indicate the median, mean and range of the detected signals (n > 20 image fields with ~4 cells per image per sample type, each sample run at least in duplicate) from three independent experiments in each case. (C) Effect of PTN (100 ng/ml) on VEGF165-induced HUVEC migration. Data are from five independent experiments and are expressed as mean ± s.e.m. percentage change in number of migrating cells compared with the non stimulated untransfected cells (control, set as default 100). Asterisks denote a statistically significant difference from control. ***P < 0.001.

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