Figure 5From: Oncogenic KRAS promotes malignant brain tumors in zebrafish MEK inhibitor U0126 suppresses proliferative effect of oncogenic KRAS in skin epithelial cells. (A) Graphic representation of driver and effector DNA constructs for generation of Dox-inducible stable transgenic lines. (B, C) In an inducible Tg(krt5:rtTA:mCherryKRAS G12V) transgenic line, 48hpf larvae treated with 10 μg/ml Dox showed skin hyperplasia, most noticeably under the yolk sac (arrows). 50 μM U0126 treatment completely eliminated the skin hyperplasia (arrow heads). Scale bar, 250 μm.Back to article page