NTSR1-selective antagonist SR48692 inhibited glioma progression
. A, General observation showed that brain swelling was present in the mice of the control group (dotted black circle) after 10 days of intracranial incubation, scale bar = 1 cm. Glioma progressed and invaded the contralateral tissue during the early stages of tumor formation in the control group (black arrows). H.E. staining. Bar = 1 mm. B, The MRI detection revealed the growth of intracranial tumors in the 10 mg/kg SR48692 treatment group and the control group. Scale bar = 5 mm. The Tv curve was also showed. #
p < 0.01 vs. the control group. Kaplan-Meier survival curve of the glioma-bearing mice in the control group and the SR48692 treatment groups. p values vs. the control group are indicated. The MRS analyses in voxels placed in tumor core (blue square) and peritumoral regions (red square) showed the Cho/NAA ratios and Cho/Cr ratios between the SR48692 treatment group and the control group. The P values vs. the control group are indicated. C, H.E. staining showed the margin of gliomas (black dotted line) in the control group and the 5 mg/kg SR48692 treatment group Scale bar = 100 μm. D, NTS immunoreactivity was observed in syngeneic xenografts using IHC staining. The images with a larger magnification in the corner of figures. Scale bar = 100 μm.