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Table 1 NRAS mutant cell lines and their characteristics

From: Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma

Cell line

NRAS mutation

Other known mutations

M202

NRASQ61L

EGFR amplification

CDKN2A homozygous deletion

M207

NRASQ61L

MITF amplification

EGFR L747_P753 > S

PTEN heterozygous deletion

M243

NRASQ61H homozygous

PTENE156G heterozygous

CTNNB1_D32Y

M244

NRASQ61K heterozygous

 

M245

NRASQ61K heterozygous

TP53R273H

M249AR4

NRASQ61K heterozygous

MITF amplification

BRAFV600E heterozygous

PTEN homozygous deletion

AKT2 amplification

M296

NRASQ61R heterozygous

 

M311

NRASQ61L homozygous

 

M318

NRASQ61L heterozygous

PIK3CAC420R

M376

NRASQ61K heterozygous

 

BRAFV600E heterozygous

M408

NRASQ61K heterozygous

 

SBCL2

NRASQ61K homozygous

 

SKMEL173

NRASQ61K

CTNNB1 D32G

CCND1 amplification

WM1366

NRASQ61L heterozygous