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Figure 9 | Molecular Cancer

Figure 9

From: Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner

Figure 9

Downregulation of Notch1 reverses EMT in vivo . (A) Tumor growth curve. The tumor volume in nude mice injected with MDA-MB-231-shNotch1 cells was significantly smaller than that of the control MDA-MB-231-shNC cells. Tumor volumes represent means ± SD, n = 4 per group, the symbol * represents a significant difference (P < 0.05). (B) In vivo metastasis assays of MDA-MB-231 cells with or without Notch1 downregulation. (C) Representative images of immunohistochemical staining for the EMT-related markers E-cadherin and N-cadherin as well as hematoxylin and eosin staining (magnification: 400×). The data are from three independent experiments.

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Molecular Cancer

ISSN: 1476-4598