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Table 3 Univariate and multivariate Cox regression analysis of clinical factors and the 31-gene prognostic signature in colorectal samples

From: A molecular signature for the prediction of recurrence in colorectal cancer

Parameters

No. of patients

Univariate

Multivariate

P value

HR (95% CI)

P value

HR (95% CI)

Gender

 

0.303

1.321 (0.778-2.243)

0.940

1.022 (0.571-1.830)

Male

117

    

Female

83

    

Age

 

0.889

0.963 (0.656-1.641)

0.161

0.662 (0.372-1.178)

<60

113

    

> = 60

87

    

Tumor size

 

0.323

1.323 (0.759-2.308)

0.450

1.260 (0.692-2.296)

<5

141

    

> = 5

59

    

Location

 

0.376

0.776 (0.442-1.362)

0.895

0.961 (0.533-1.734)

Colon

77

    

Rectal

123

    

Gross appearance

 

0.820

1.062 (0.631-1.788)

0.599

0.863 (0.499-1.493)

Exophytic

39

    

Ulcerative

5

    

Infiltrative

156

    

Differentiation

 

0.440

1.269 (0.693-2.323)

0.546

1.227 (0.631-2.388)

High

6

    

Moderate

153

    

Low

41

    

Stage

 

<0.001

3.568 (1.912-6.660)

0.701

1.243 (0.410-3.764)

II

95

    

III

105

    

T stage

 

0.025

1.727 (1.069-2.790)

0.074

1.524 (0.960-2.420)

T2

15

    

T3

80

    

T4

105

    

N stage

 

<0.001

2.569 (1.801-3.665)

0.024

2.101 (1.104-3.997)

N0

96

    

N1

75

    

N2

29

    

Prognostic signature

 

<0.001

7.445 (3.835-14.454)

<0.001

6.752 (3.347-13.622)

High risk

83

    

Low risk

117

    
  1. Bold text denotes P<0.05.
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Molecular Cancer

ISSN: 1476-4598