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Figure 4 | Molecular Cancer

Figure 4

From: Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

Figure 4

KCNJ2/Kir2.1 affects the cell cycle distribution of SCLC cells after ADM treatment. (A) Representative FACS profiles are shown. The numbers indicate the percentages of cells in the G0/G1, S and G2/M phases. (B) Histographs for the cell cycle distribution of SCLC cells. H69 and H446 cells stably transfected with KCNJ2 expression plasmid (H69-KCNJ2 and H446-KCNJ2) showed an increased proportion in the G0/G1 phase and a decreased proportion in the S phase when compared with H69-NC and H446-NC, respectively. KCNJ2/Kir2.1-knockdown cells (H69AR-shKCNJ2-1, H69AR-shKCNJ2-2, H446AR-shKCNJ2-1 and H446AR-shKCNJ2-2) showed a decreased proportion in the G0/G1 phase and an increased proportion in the S phase when compared with H69AR-shNC or H446AR-shNC. Data are shown as the means ± SD from three independent experiments. *, P < 0.05; **, P < 0.01 compared with the corresponding NC cells transfected with pcDNA3.1 empty vector or shNC.

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