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Figure 6 | Molecular Cancer

Figure 6

From: Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

Figure 6

KCNJ2/Kir2.1 enhances SCLC tumor growth in vivo . (A, C) Tumors formation and growth curves of tumor volumes formed by H69 and H69AR cells with altered KCNJ2 expression.1, H69; 2, H69-NC; 3, H69-KCNJ2; 4, H69AR; 5, H69AR-NC; 6, H69AR-shKCNJ2-1; 7, H69AR-shKCNJ2-2. (B, D) Tumors formation and growth curves of tumor volumes formed by H446 and H446AR cells with altered KCNJ2 expression. 1, H446; 2, H446-NC; 3, H446-KCNJ2; 4, H446AR; 5, H446AR-NC; 6, H446AR-shKCNJ2-1; 7, H446AR-shKCNJ2-2. (E) Kir2.1 expression was examined by IHC in the tumor xenografts originating from H69-NC, H69-KCNJ2, H69AR-NC and H69AR-shKCNJ2-1 cells. Representative images were shown. Brown chromogen represents positive staining. Scale bar, 50 μm. (F) Kir2.1 and MRP1/ABCC1expression were evaluated by staining scores in the tumor xenografts. *, P < 0.05 compared with the corresponding NC cells transfected with pcDNA3.1 empty vector or shNC.

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