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Figure 7 | Molecular Cancer

Figure 7

From: Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

Figure 7

Kir2.1 interacts with MRP1/ABCC1 expression. (A-B) qRT-PCR (A) and Western blotting (B) analyses showed that KCNJ2/Kir2.1 upregulation or downregulation successfully elevated or suppressed MRP1/ABCC1 mRNA and protein levels, respectively. (C) The interaction between Kir2.1 and MRP1/ABCC1 was analyzed by Co-IP. Anti-Kir2.1 antibody was used for IP. The amounts of ABCC1 and Kir2.1 in the immunoprecipitates were detected by Western blotting with the indicated specific antibodies.

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Molecular Cancer

ISSN: 1476-4598