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Figure 9 | Molecular Cancer

Figure 9

From: Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway

Figure 9

KCNJ2 is a direct target of miR-7. (A) The miR-7levels in H69, H69AR, H446, H446AR cells were measured after transfection with an miR-7 agomir or antagomir or the corresponding NC. (B-D) KCNJ2/Kir2.1 and MRP1/ABCC1expression at mRNA and protein levels was assessed after transfection of SCLC cells with an miR-7 agomir or antagomir or the corresponding NC. (E) A dual luciferase assay was performed in H69 cells transfected with the luciferase construct alone or cotransfected with anmiR-7 agomir or antagomir or the corresponding NC. *, P < 0.05; **, P < 0.01 compared with the corresponding NC cells transfected with NC agomir or NC antagomir.

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Molecular Cancer

ISSN: 1476-4598