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Figure 7 | Molecular Cancer

Figure 7

From: Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression

Figure 7

The correlation of pSer 21 GSK3α /pSer 9 GSK3β expression with cyclin D1 transcription in various OSCC samples. (A) RT-PCR showing cyclin D1 mRNA expression (201 bp PCR product) in different normals (lane 1–3), PMLs (lane 4–6) and oral cancer samples of various stages (T1-T2 samples lane 7–10; T3-T4 samples lane 11–15). GAPDH expression (410 bp PCR product) was used as a control in this experiment. (B) A histogram showing the level of expression of cyclin D1 mRNA in various groups (N-Normal, PML, T-Tumor) of samples as indicated. No significant correlation (C) of cyclin D1 mRNA expression and pSer21GSK3α protein expression was observed, and a positive correlation (D) between cyclin D1 mRNA expression and the expression of pSer9GSK3β was observed.

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