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Figure 8 | Molecular Cancer

Figure 8

From: Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression

Figure 8

A proposed model for defining GSK3-mediated deregulation of cell division in oral cancer. Diverse upstream signaling pathways and regulatory molecules contribute to the loss of function of GSK3 by reversible phosphorylation, inactivating GSK3. These functionally altered GSK3 may shift to various cellular compartments, fuel cyclin D1 transcription possibly by increasing the activity of various TFs or may remain silent, due to degrading cyclin D1 or activating p53, to transform the oral mucosa leading to OSCC.

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