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Table 1 Expression of GSK3α/GSK3β in various OSCC and control samples - their correlation with clinico-pathological parameters

From: Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression

Sl. No. Groups Total (N = 80) GSK3α GSK3β p-value (GSK3β over GSK3α )
Expression Overexpression Expression Overexpression Expression Overexpression
1 Age        
 ≤40 15 08 (53.3%) 00 (00.0%) 09 (60.0%) 03 (20.0%) NS 0.06
 >40 ≤ 70 53 25 (47.1%) 05 (09.4%) 36 (67.9%) 20 (37.7%) 0.03 0.0006
 >70 12 06 (50.0%) 00 (00.0%) 09 (75.0%) 07 (58.3%) NS 0.001
2 Sex        
 Male 49 26 (53.0%) 04 (08.1%) 33 (67.3%) 19 (38.7%) NS <0.0001
 Female 31 13 (41.9%) 01 (03.2%) 20 (64.5%) 10 (32.2%) NS 0.002
3 Size        
 T1-T2 40 18 (45.0%) 03 (07.5%) 30 (75.0%) 23 (57.5%) 0.006 <0.0001
 T3-T4 2 02 (100%) 00 (00.0%) 02 (100%) 01 (50.0%) NS NS
4 Lymph nodes        
 N0 42 19 (45.2%) 03 (07.1%) 28 (66.6%) 20 (47.6%) 0.04 <0.0001
 N1-N3 4 02 (50.0%) 01 (25.0%) 03 (75.0%) 03 (75.0%) NS NS
5 Distant Metastasis        
 M0 38 19 (50.0%) 03 (07.8%) 28 (73.6%) 19 (50.0%) 0.03 <0.0001
 M1 8 03 (37.5%) 01 (12.5%) 07 (87.5%) 07 (87.5%) 0.03 0.002
6 Histological grade        
 WDSCC 24 17 (70.8%) 02 (08.3%) 21 (87.5%) 18 (75.0%) NS <0.0001
 MDSCC 7 03 (42.8%) 01 (14.2%) 07(100%) 05 (71.4%) NS NS
 PDSCC 7 02 (28.5%) 01 (14.2%) 04 (57.1%) 03 (42.8%) NS NS
7 Oral cancer types        
 SCC 32 18 (56.2%) 03 (09.3%) 27 (84.3%) 24 (75.0%) 0.02 <0.0001
 Invasive SCC 5 02 (40.0%) 01 (20.0%) 03 (60.0%) 03 (60.0%) NS NS
 Mucoepidermoid carcinoma 8 04(50.0%) 01 (12.5%) 06 (75.0%) 03 (37.5%) NS NS
 Adamantinoma 8 03 (37.5%) 0 (00.0%) 05 (62.5%) 01 (12.5%) NS NS
 Adenoid cystic carcinoma 3 00 (00.0%) 00 (00.0%) 00 (00.0%) 00 (00.0%) N/A N/A
 Basal cell carcinoma 2 00 (00.0%) 00 (00.0%) 01 (50.0%) 00 (00.0%) N/A N/A
 Acinic cell carcinoma 1 00 (00.0%) 00 (00.0%) 01 (50.0%) 00 (00.0%) N/A N/A
9 Hyperplasia of Squamous Epithelium 6 03 (50.0%) 01 (16.6%) 04 (66.6%) 01 (16.6%) NS NS
10 Cancer adjacent oral tissue 5 01 (20.0%) 00 (00.0%) 03 (60.0%) 00 (00.0%) NS NS
11 Non neoplastic oral cavity glands 11 07 (63.6%) 00 (00.0%) 06 (54.5%) 00 (00.0%) NS NS
12 Normal oral squamous epithelium 4 03 (75.0%) 00 (00.0%) 01 (25.0%) 01 (25.0%) NS NS
13 Sub-types of OSCC        
 Tongue 10 08 (80.0%) 01 (10.0%) 08 (80.0%) 07 (70.0%) NS 0.006
 Lip 7 03 (42.8%) 00 (00.0%) 07 (100%) 07 (100%) 0.01 0.0002
 Cheek 6 03 (50.0%) 00 (00.0%) 05 (83.3%) 03 (50.0%) NS 0.04
 Gingiva 4 02 (50.0%) 00 (00.0%) 04 (100%) 04 (100%) NS 0.004
 Others 5 02 (40.0%) 03 (60.0%) 03 (60.0%) 03 (60.0%) NS NS