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Figure 4 | Molecular Cancer

Figure 4

From: Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity

Figure 4

Effects of inhibition of IL-6 signaling on proliferation and colony-formation of LHB-expressing cells. (A) Phosphorylated stat3, stat3 and actin were analyzed by immunoblotting. (B) Designated cells were treated with JSI-124 (10 μM), a Jak2 inhibitor, and their proliferation was assessed. (C) Colony-forming ability of LHB-expressing cells was examined by a colony forming assay in the absence or presence of JSI-124. (D and E) Cells were transfected with siRNAs (200 nM) targeting JAK2 (D), stat3 (E) or control scrambled siRNAs as indicated. Cells proliferation was analyzed by MTT assay. Data represent means ± SD. **P < 0.01, ***P < 0.001.

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Molecular Cancer

ISSN: 1476-4598