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Table 1 IRF5 interacting partners in MDA-MB-231 cells

From: A conserved region within interferon regulatory factor 5 controls breast cancer cell migration through a cytoplasmic and transcription-independent mechanism

Identified protein

IRF5/EV ratio

Interferon Regulatory Factor 5

32.9

Tubulin alpha-1C chain

26.0

Mitochondrial heat shock 60kD

7.1

Similar to Homo sapien solute carrier family 25

5.5

Similar to transketolase

5.5

Similar to EF2

4.7

Filaggrin

4.7

Fructose-bisphosphate aldolase

3.1

Similar to protein disulfide-isomerase A6

2.7

Clathrin heavy chain 2

2.7

Flap endonuclease 1

2.7

Filamin-C

2.7

Triosephosphate isomerase

2.4

Myosin-9

2.4

Ribosomal protein L12 variant

2.4

Eukaryotic translation intiation factor 3 sub. D

2.4

Mannosyl-oligosaccharide glucosidase

2.4

U4/U6 snRNA Prp31

2.4

  1. Following immunoprecipitation of FLAG from FLAG-tagged EV- or IRF5-231 cells, IP lysate was analyzed by mass spectrometry. Binding of proteins identified was normalized to EV-231 FLAG levels. Proteins showing a greater than 2-fold increase in binding are shown.