Figure 5
From: The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis
CCL21/CCR7 pair correlates with lymphangiogenic markers in a panel of breast cancer tissues. (A) Quantitative real-time PCR analysis of CCL21, CCR7 and VEGF-C mRNA expression in control (adjacent non-tumor) and tumoral tissues. Data are represented as a mean ± SD. (*) indicates significant differences (p < 0.05). (B), (C), (D) mRNA expression level of CCR7 is positively correlated with the expression of lymphatic vascular markers (LYVE1, Podoplanin, VEGF-C) in primary breast cancer samples; Pearson’s coefficient indicates strong correlations. (E) mRNA expression level of CCR7 and blood vessel marker CD31 in primary breast cancer samples. Pearson’s coefficient suggests little to no correlation between the two variables. Data represent mean values from three independent experiments.