Figure 6
From: The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis
Schematic diagram of the proposed role of CCL21/CCR7 axis in lymphangiogenesis. (A, B) Molecular crosstalk between tumor cells and LECs. 1) Tumor cells enhance the expression of VEGF-C in response to CCL21/CCR7 signaling and promote sprouting of new lymphatics. 2) CCR7-expressing LECs have a direct lymphangiogenic potential by stimulating the pro-lymphangiogenic traits of LECs. 3) LECs respond to CCL21/CCR7 axis through the modulation of VEGFR-3 signaling pathway.