Figure 5
Proteins more abundant upon cysteine cathepsin inhibition. The connectivity of all proteins more abundant (log2 Fc ≥ 0.58) in the quantitative proteome comparison of TGFβ-1 treated to TGFβ-1 + E64d treated iPL32 cells was determined with STRING (Search Tool for the Retrieval of interacting Genes/Proteins). The three clusters most significantly enriched: lysosome p = 2.3 x 10−12, endosome p = 4.6 x 10−7, proteasome p = 4.2 x 10-12, and Jam-a “f11r” are highlighted. Different line colors indicate the type of evidence for interaction.