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Figure 6 | Molecular Cancer

Figure 6

From: The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression

Figure 6

SPRY4-IT1 promotes breast cancer cell proliferation partly through the upregulation of ZNF703 expression. (A) An MTT assay was performed to determine the proliferation of MDA-MB-231 cells transfected with scrambled siRNA, pCDNA-ZNF703,si-SPRY4-IT1 + pCDNA-ZNF703 or si-SPRY4-IT1. (B) An MTT assay was performed to determine the proliferation of MDA-MB-231 cells transfected with scrambled siRNA, si-ZNF703, si-SPRY4-IT1 + si-ZNF703 or si-SPRY4-IT1. The data are presented as the means ± S.D. from three independent experiments. *P < 0.05. (C, D) Colony-forming growth assays were performed to determine the proliferation of MDA-MB-231 treated with scrambled siRNA, pCDNA-ZNF703, si-SPRY4-IT1 + pCDNA-ZNF703, si-ZNF703, si-SPRY4-IT1 + si-ZNF703, or si-SPRY4-IT1. (E, F) Apoptosis in MDA-MB-231 cells treated with scrambled siRNA, si-SPRY4-IT1 + pCDNA-ZNF703, si-SPRY4-IT1 + si-ZNF703, or si-SPRY4-IT1 was detected through TUNEL.

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