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Figure 3 | Molecular Cancer

Figure 3

From: Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2

Figure 3

ITLN1 facilitates the expression of KLF4 via inactivation of PI3K/AKT signaling. (A) Western blot showing the phosphorylation of AKT (T308 and S473) and expression of KLF4 in solvent (mock)- or recombinant ITLN1-treated SH-SY5Y (1 and 2 μg/ml for 24 hrs) and SK-N-BE(2) (1 μg/ml for 24 and 36 hrs) cells. (B) Western blot showing the phosphorylation of AKT (T308 and S473) and expression of KLF4 in NB cells stably transfected with sh-Scb or sh-ITLN1, and those pre-treated with LY294002 (10 μmol/L).

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Molecular Cancer

ISSN: 1476-4598