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Figure 1 | Molecular Cancer

Figure 1

From: miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6

Figure 1

miR-211 is downregulated in epithelial ovarian cancer (EOC) tissues and cell lines. A. Expression of miR-211 was lower in clear cell ovarian carcinomas (CCOC, n = 9) and high-grade serous ovarian carcinomas (HGSC, n = 12) compared to ovarian surface epithelial cells (OSEC, n = 9) (GSE47841, p < 0.001). B. Levels of miR-211 were lower in 60 EOC tissues compared to 20 normal epithelial tissues samples. **p < 0.01. Relative levels of miRNA expression normalized to U6 snRNA was determined by setting the miRNA expression levels of normal epithelial tissue samples to 1. C. miR-211 expression was downregulated in six EOC cell lines (OVCAR3, Caov3, OVCA429, SKOV3, A2780 and COV644) compared to human ovarian surface epithelial (HOSE) cells. Relative levels of miRNA expression normalized to U6 snRNA was determined by setting the miRNA expression levels of HOSE cells to 1. *p < 0.05, **p < 0.01. Data are presented as mean ± SEM of three independent experiments.

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