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Figure 3 | Molecular Cancer

Figure 3

From: Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma

Figure 3

YAP1 is a target of miR-15a and miR-16-1 in GAC. (A) The miR-15a and miR-16-1 binding sites in YAP1 3′UTR as TargetScan predicted (www.targetscan.org). (B) The YAP1 mRNA expression after ectopic miR-15a and miR-16-1 expression in AGS, MKN1, MGC-803 and NCI-N87 cells (**, P < 0.001). (C) miR-15a and miR-16-1 transfection down-regulated YAP1 protein expression in GAC cells. (D) miR-15a and miR-16-1 suppressed the luciferase activities in the constructs containing wild-type binding sites in YAP1 3′UTR, but for the constructs containing the deletion binding sites, miR-15a and miR-16-1 had no suppressive effect on the luciferase activities. (E1) miR-15a showed negative correlation with YAP1 protein expression (P = 0.048). (E2) miR-16-1 expression was negatively correlated with YAP1 protein expression (P = 0.010).

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Molecular Cancer

ISSN: 1476-4598