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Figure 4 | Molecular Cancer

Figure 4

From: Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma

Figure 4

siRNA-mediated YAP1 knockdown suppressed GAC cell proliferation in vitro and in vivo . (A) YAP1 knockdown suppressed cell proliferation in MGC-803, NCI-N87 and SGC-7901 cells (**, P < 0.001). The 575 nm absorbance readings in Day 6 were calculated for the P-Value. (B) siYAP1-MGC-803 formed smaller xenografts than siScramble-MGC-803 control in nude mice (**, P < 0.001). The tumor sizes in the Day 28 were calculated for the P-Value. (C) YAP1 knowdown decreased the expression of CCND3, CDK6 and p-Rb, but increased the expression of p21 and p27. The cleaved-PARP showed activated expression in AGS and MGC-803 cells upon YAP1 knockdown.

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