Figure 10From: Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway Phosphorylation ERK was specific activated in LSCs. Phosphorylation ERK was intrinsic and spontaneous activated in LSCs, which led to drug resistance for clinical chemo-agents. In contrast, the bulk leukemia cells were more sensitive to chemical drugs and eventually involved in apoptosis.Back to article page