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Figure 9 | Molecular Cancer

Figure 9

From: Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

Figure 9

The proposed mechanism for survivin overexpression in LSCs. (A) TNF-α stimulation leads to transactivation of TNFR, which activates ERK/MSK/Sp1 pathways. This activation, together with c-Myc, concurrently regulates survivin expression in LSCs, facilitating LSCs growth, allowing LSCs escape from apoptosis (B), and finally permitting the evolution to the “Seed cell” in acute myeloid leukemia (C). The straight arrow represented activation, the dotted arrow represented none affection, and TBP and RNA PII represented the transcription initiation complex.

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Molecular Cancer

ISSN: 1476-4598