TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas

Table 1 Neuroblastoma characteristics and their modulation by TNFα

		MYCN non-amplified [ 36 , 37 ]				MYCN amplified [ 36 , 37 ]
		SK-N-AS	SK-N-SH	CHLA90	SH-SY5Y	LAI-5S	SK-N-BE(2)	IMR32	Tet21N
Expression	Fas	+	+	+/−	+/−	-	-	+	++
	Caspase-8	++	++	+/−	-	+/−	+/−	-	++
	p53	N [38]	F [39]	N [40]	F [39]	N [41]	N [40]	F [39]	F [39]
TNFα-induced	Fas	++	+	+	-	-	-	-	++
TNFα-induced	Sensitization to etoposide/cisplatin	++	+	NA	-	-	NA	NA	NA
FasL-induced cell death	UT	+	+/−	-	-	-	-	-	++
FasL-induced cell death	TNFα	+++	+++	+	-	-	-	-	+++

ISSN: 1476-4598