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Table 1 Neuroblastoma characteristics and their modulation by TNFα

From: TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas

  MYCN non-amplified [ 36 , 37 ] MYCN amplified [ 36 , 37 ]
SK-N-AS SK-N-SH CHLA90 SH-SY5Y LAI-5S SK-N-BE(2) IMR32 Tet21N
Expression Fas + + +/− +/− - - + ++
Caspase-8 ++ ++ +/− - +/− +/− - ++
p53 N [38] F [39] N [40] F [39] N [41] N [40] F [39] F [39]
TNFα-induced Fas ++ + + - - - - ++
Sensitization to etoposide/cisplatin ++ + NA - - NA NA NA
FasL-induced cell death UT + +/− - - - - - ++
TNFα +++ +++ + - - - - +++
  1. Abbreviations: F Functional, N Non-functional, NA Not available.