The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon

Table 1 Correlation matrix for expression of CaSR and EMT markers in human colorectal cancer samples

	CaSR	N-Cadherin	E-Cadherin	TWIST1	αSMA	Vimentin	β-Catenin	FSP1	SLUG
CaSR	1.000	-.267^**	.314^**	-.212^*	-.259^**	-.227^*	-.248^**	-.152	-.397^**
N-Cadherin	-.267^**	1.000	-.157	.015	.178	.136	.100	.209^*	.118
E-Cadherin	.314^**	-.157	1.000	-.297^**	-.230^*	-.362^**	-.157	-.322^**	-.322^**
TWIST1	-.212^*	.015	-.297^**	1.000	.193^*	.259^**	.101	.417^**	.417^**
αSMA	-.259^**	.178	-.230^*	.193^*	1.000	.657^**	-.054	.559^**	.358^**
Vimentin	-.227^*	.136	-.362^**	.259^**	.657^**	1.000	.077	.432^**	.529^**
β-Catenin	-.248^**	.100	-.157	.101	-.054	.077	1.000	-.057	.256^**
FSP1	-.152	.209^*	-.322^**	.417^**	.559^**	.432^**	-.057	1.000	.408^**
SLUG	-.397^**	.118	-.322^**	.417^**	.358^**	.529^**	.256^**	.408^**	1.000

Correlation analysis was performed across 111 human colorectal cancer samples of tumor and adjacent non-tumor mucosa. Spearman correlation coefficient and corresponding p value is shown. **p< 0.01, *p< 0.05.

ISSN: 1476-4598