DCA affects paclitaxel resistance in cells with damaged mitochondria. (A) Transmission electron microscopy of mitochondrial morphology in mitochondrial respiration-deficient A549/MD cells. (B) Release of 14C-CO2 from A549/MD cells. (C) Viability of A549, A549/Taxol and A549/MD cells treated with DCA for 48 h. (D) IC50 for paclitaxel in A549, A549/Taxol and A549/MD cells after treatment for 48 h with 0 and 10 mM DCA. *P < 0.05. Data are mean ± SEM of three independent experiments.