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Figure 3 | Molecular Cancer

Figure 3

From: SapC-DOPS nanovesicles induce Smac- and Bax-dependent apoptosis through mitochondrial activation in neuroblastomas

Figure 3

SapC-DOPS induces loss of mitochondrial potential (ΔΨM). A) Dose- and time-dependent changes in ΔΨM evaluated by JC-1 ratio of red and green fluorescence following SapC-DOPS treatment in SK-N-SH and IMR-32 cells. B) ΔΨM measured by JC-1 ratio in bongkrekic acid-pretreated SK-N-SH cells following SapC-DOPS treatment for 24 h. C) Viability measured by MTT assay in SK-N-SH cells following pre-treatment with bongkrekic acid (BA) and subsequent treatment with 50 μM SapC-DOPS for 72 h. *P < 0.05, **P < 0.001 when compared to control. Points, mean of three to five independent experiments; bars, SE.

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