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Figure 1 | Molecular Cancer

Figure 1

From: MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma

Figure 1

miR-377 expression in normal melanocytes and melanoma and its re-expression following treatment with epigenetic modifiers. (A) The expression levels of miR-377 in different melanoma cell lines relative to NHEM was assessed by qRT-PCR and normalized by Rnu48. (B) The expression levels of miR-377 in normal melanocytes, thirteen samples of benign nevi and six samples of melanoma as assessed by qRT-PCR and normalized by Rnu43. Each diamond represents one patient. The red thick lines represent the median. *signifies p < 0.05. (C) The expression levels of miR-377 in melanoma cells treated with epigenetic modifiers (10 μM 5-Aza and 3 mM PBA) for 96 h, as assessed by qRT-PCR and normalized by Rnu19. The results are presented as relative expression to NHEM. Data is represented as mean ± SEM from three independent experiments.

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