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Figure 3 | Molecular Cancer

Figure 3

From: MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma

Figure 3

MiR-377 effect on melanoma cells migration. (A) The migration of mel33B1 and mel-14PA melanoma cell lines stably transfected with HTR control vector or vector expressing miR-377 was assessed using the in-vitro transwell method 24 h after seeding. Representative micrographs of the transwell membrane are shown; Quantification of the area covered by the cells was performed using the ImageJ software [20] following three independent experiments; p value was calculated by t-test**p < 0.01;***p < 0.001 (B) Cellular migration was also assessed using the xCELLigence real-time system (for both cell lines as written above the graphs). For determination of statistical significance, a repeated measures two-way ANOVA with Bonferroni post-hoc tests was performed; *p < 0.05, **p < 0.01, ***p < 0.001.

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