Changes in the FOXM1 target gene network in late stage OAC. (A) Box plots of mRNA levels of the indicated genes in OAC tissue samples grouped according to T stage, the presence of local metastases (absent, n = 18; present, n = 37) or the presence of distal metastases (absent, n = 38; present, n = 18). Early and late T stage was defined as stage 1 or 2 disease (n = 16) and stage 3 or 4 disease (n = 32) respectively. The mRNA level relative to the median level of normal tissues (taken as 1; grey lines) is shown. Boxes represent the interquartile range and the median value is indicated by the horizontal line. Open black circles represent outliers. Statistical significance is indicated (** P-value <0.01; * P-value <0.05). (B) Summary of the changes in expression of FOXM1 and genes encoding MMB/DREAM complex components in OAC samples (red and blue represent down and up regulated in OAC respectively) leading to general upregulation of the FOXM1 target gene network.