Distinct DNA methylation levels in HCC and non-tumor livers. (A) Hierarchical unsupervisedclustering and corresponding heatmap of the methylation status in 17 WNA HCCs and the 17 matching non tumorous livers. Clustering was obtained using a 1-rank correlation distance calculation and an average linkage on DChip software. T symbolyzes the tumor samples whereas N corresponds to the non-tumor liver counterparts. (B) Comparison of the methylation rates as detected at the different loci in the 45 HCC and the 17 Non-tumor livers. (C) Methylation Index in HCC and matching non-tumor liver DNA from the same patient. Lines link the dots corresponding to T and NT specimens of the same patient.