Figure 4From: TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma Impact of TP53 ARG72PRO on the expression of genes involved in DNA methylation metabolism. (A) Panel of liver cancer cell lines wild-type for TP53 used for in vitro experiments. (B) Western-blot analysis of p53 expression (baseline and doxorubicin-induced) in the panel of cell lines. +: indicates doxorubicin treatment, 0.2 μM/72 h. (C) qRT-PCR analysis of genes involved in DNA methylation metabolism. All cells were treated 48 h by 0.5 μM doxorubicin. P values are obtained by ANOVA analysis.Back to article page