Figure 5

miR-320a downregulation correlates with metastasis and poor patient survival in SACCs. (A) In situ hybridization for miR-320a and immunohistochemical staining for integrin β3 in primary SACCs with metastasis vs. those without metastasis (200×). Quantification of miR-320a and integrin β3 expression in primary SACC samples from the affiliated hospitals of Sun Yat-sen University (B) or from the affiliated hospitals of Central South University (C). ***P < 0.001. Kaplan-Meier curves for SACC patients from the affiliated hospitals of Sun Yat-sen University comparing miR-320a expression and metastasis (D) or miR-320a expression and survival (E) was analyzed by the log rank test. Kaplan-Meier curves for SACC patients from the affiliated hospitals of Central South University comparing miR-320a expression and metastasis (F) or miR-320a expression and survival (G). The median value was used to distinguish high expression and low expression.