Skip to main content
Figure 4 | Molecular Cancer

Figure 4

From: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

Figure 4

TIC9 and ONC201/TIC10 induce tumor cell death and ONC201/TIC10-induced cell death is tumor-selective. (a) Sub-G1 DNA content of HCT116 p53−/− cells treated with TICs for indicated time periods (1 μM, n = 3). (b) Cell cycle profiles of HCT116 p53−/− cells treated with TICs (5 μM, 72 hr). (c) Sub-G1 DNA content of HCT116 p53−/− cells treated with TICs (72 hrs, 5 μM, n = 3). (d) Sub-G1 DNA content of HFF normal human fibroblasts treated with TICs (72 hr, 5 μM, n = 3). (e) Cell viability assay of HCT116 or HFF cells treated with ONC201/TIC10 at the indicated doses (72 hr, n = 3). Error bars represent standard deviation.

Back to article page

Molecular Cancer

ISSN: 1476-4598