Figure 7From: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway ONC201/TIC10 and TIC9 exclusively affect Akt/ERK/Foxo3a. Western blot analysis of HCT116 p53−/− cells treated with TICs in HCT116 p53−/− cells (5 μM, 60 hr).Back to article page