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Table 1 Correlations between clusters and clinico-pathological parameters

From: Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer

Clinico-pathological parameter

Cluster

Correlation (r)

p value

Gene name

Correlation

Cq mean (SEM)

p value

TNM

T cells

0.37

0.007

FOXP3

0.388

 

0.004

    

CD3E

0.374

 

0.006

Vaso-invasion

Inflammation

0.38

0.005

IL6

  

0.002

     

absent

−0.486 (0.193)

 
     

present

0.348 (0.173)

 

Lymph node metastasis

   

LGALS9

  

0.008

     

negative

0.277 (0.166)

 
     

positive

−0.492 (0.220)

 
    

IL2

  

0.003

     

negative

0.306 (0.176)

 
     

positive

−0.518 (0.171)

 
  1. Correlations between normalized Cq values of cluster first principal components or separate genes and clinico-pathological parameters with p < 0.008 are shown (for the correlation between LGALS9 and lymph nodes p = 0.0077). The correlations between single gene expression and TNM stage were tested by the Pearson correlation test and since increased Cq values represent decreased expression, an inverse correlation was found. The correlations for separate genes and vaso-invasion or lymph nodes were tested using independent samples t-tests. Mean normalized Cq values of the gene expression within a category are given to indicate the direction of correlation (inverse for vaso-invasion).
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Molecular Cancer

ISSN: 1476-4598