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Figure 6 | Molecular Cancer

Figure 6

From: Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer

Figure 6

NFκB activation is associated with mTOR and autonomously-produced TNFα. a) Effect of mTOR on RelA activation in OVSAYO cells cultured under hypoxia. b) TNFα production in OVSAYO cells cultured under SSH for 24 h. c) Effect of TNFα on synergistic ICAM1 activation in cells transfected with siRNAs, as indicated. Data shown are the mean (n = 3) ± SD. *P = 0.018. Inset: western blot analysis of ICAM1 expression in cells transfected with the indicated siRNAs and cultured under SSH for 24 h. d) Effect of TNFα on RelA activation under SSH in OVSAYO cells. e) Model of ICAM1 induction under SSH. Solid arrows, dashed arrows, and “p”s with bursts are indicative of the activation process, protein induction, and active (phosphorylated) states, respectively.

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Molecular Cancer

ISSN: 1476-4598