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Figure 7 | Molecular Cancer

Figure 7

From: Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer

Figure 7

LCFAs are responsible for the synergistic activation of ICAM1 . a) mRNA levels of ICAM1 in OVSAYO cells cultured under SSH for 16 h with HP- or LP-Alb. Data shown are the mean (n = 2) ± SD. b) ICAM1 and VEGF mRNA expression levels in cells cultured with 1% serum for 16 h. N, normoxia (20% O2); H, hypoxia (1% O2). Data shown are the mean (n = 3) ± SD. c) ICAM1 expression in cells cultured as in a) in the presence or absence of HP-Alb and various LCFAs. Data shown are the mean (n = 2) ± SD. d) Staining of neutral lipids in OVSAYO cells cultured as in a) with or without albumin. e) Quantitative representation of d). Fluorescence areas were quantified using ImageJ software. Data shown are the mean (n = 6) ± SD. *P = 0.0002.

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Molecular Cancer

ISSN: 1476-4598