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Figure 8 | Molecular Cancer

Figure 8

From: High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma

Figure 8

Involvement of the PI3K/AKT pathway in PP4C-induced MMP-2 and MMP-9 expression and activation and cell invasion. (A) Levels of p-AKT, T-AKT, MMP-2 and MMP-9 were evaluated in SW480 and HT29 cells after the indicated treatment. (B, C) The MMP gelatinase activity was determined after the indicated treatment. (D) Matrigel cell invasion was evaluated in SW480 and HT29 cells transfected with either vector control or PP4C followed by treatment with the PI3K inhibitor Ly294002 (25 μmol).

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Molecular Cancer

ISSN: 1476-4598