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Table 4 Significantly up- and downregulated sncRNAs

From: Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

a) Downregulated in PDAC      
sRNA NEV normal NEV PDAC Log2 FoldChange FDR Previously shown
hsa-miR-216b 57,650.3 99.6 9.2 0.0000000 [7,8,11]
hsa-miR-216a-3p 3,218.9 4.1 9.6 0.0000000 [7,8,11]
hsa-miR-217 86,322.3 143.1 9.2 0.0000000 [7-9,11]
hsa-miR-216a-5p 35,959.9 144.7 8.0 0.0000000 [7-9,11]
hsa-miR-802 3,702.2 2.0 10.9 0.0000000 -
hsa-miR-148a-5p 4,252.9 178.9 4.6 0.0000000 [7-9,11]
hsa-miR-2114-5p 88.5 0.9 6.6 0.0000000 -
hsa-miR-375 121,790.3 11,992.2 3.3 0.0000001 [7-9,11]
hsa-miR-130b-5p 890.4 95.1 3.2 0.0000002 [7-9,11]
hsa-miR-148a-3p 224,094.2 25,764.7 3.1 0.0000005 [7-9,11]
hsa-miR-130b-3p 3,038.0 395.2 2.9 0.0000008 [7-9,11]
hsa-miR-190b 436.6 19.5 4.5 0.0000026 -
hsa-miR-2114-3p 44.7 0.3 7.0 0.0000270 -
hsa-sno-HBII-296B 1,159.5 208.8 2.5 0.0000525 -
hsa-miR-30c-2-3p 164.1 27.1 2.6 0.0000657 [7-12]
hsa-miR-219-5p 219.7 36.4 2.6 0.0000808 [7]
hsa-piR-017061 4,818,0 951,7 2,3 0.0001447 -
hsa-miR-30a-3p 1,350.4 275.0 2,3 0.0001447 [7-9,12]
hsa-miR-29c-3p 41,297.8 8.131.4 2,3 0.0003007 [7-9,12]
hsa-sno-U104 7,726.4 1.703.0 2,2 0.0007282 -
b) Upregulated in PDAC      
hsa-miR-135b-3p 1.2 80.9 −6.1 0.0000000 [11,12]
hsa-miR-135b-5p 948.9 9,475.0 −3.3 0.0000002 [11,12]
hsa-miR-21-3p 174.6 2,117.3 −3.6 0.0000005 [7-12]
hsa-miR-708-5p 309.2 3,100.3 −3.3 0.0000022 [7,10]
hsa-miR-615-3p 1.2 97.2 −6.3 0.0000024 [7]
hsa-miR-34c-5p 47.5 475.2 −3.3 0.0000048 [11]
hsa-miR-431-5p 7.0 99.7 −3.8 0.0000062 -
hsa-miR-511 17.1 242.6 −3.8 0.0000079 -
hsa-miR-143-5p 238.7 2,089.8 −3.1 0.0000092 [7-10,12]
hsa-miR-222-3p 2,263.7 17,399.2 −2.9 0.0000131 [7-12]
hsa-miR-34c-3p 2.7 49.7 −4.2 0.0000210 -
hsa-miR-155-5p 392.4 3,458.7 −3.1 0.0000210 [7-10,12]
hsa-miR-24-2-5p 396.5 2,965.3 −2.9 0.0000407 [9,10,12]
hsa-miR-34b-3p 1.0 29.5 −4.9 0.0000681 [7,9]
hsa-miR-708-3p 24.4 188.7 −3.0 0.0001073 [7,10]
hsa-miR-223-5p 17.4 204.8 −3.6 0.0001117 [7-10,12]
hsa-miR-34b-5p 12.5 96.7 −3.0 0.0001145 [7,9,11]
hsa-miR-10a-3p 101.1 643.8 −2.7 0.0001447 [7-10]
hsa-miR-196b-5p 10.1 738.0 −6.2 0.0001832 [9,11]
hsa-miR-2355-3p 3.8 43.2 −3.5 0.0002933 -
  1. For the 20 most significantly up- and downregulated sncRNAs the mean normalized expression values (NEV) for each group is provided together with the ratio between normal and PDAC expression in log2 scale (log2FoldChange). In addition, the column “previously shown” indicates if other groups have provided evidence for the deregulation of the RNA before.