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Figure 5 | Molecular Cancer

Figure 5

From: Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas

Figure 5

A model for the consequences of RB or PTEN deletion on E2F1/FOXO tumor suppressive apoptosis. RPCs with normal RB and PTEN protein levels do not proliferate due to minimal E2F activity. In the event of an RB mutation, E2Fs are deregulated and may complex with FOXO1 to induce apoptosis and suppress tumor emergence. Deleting PTEN activates p-AKT, causing p-FOXO1 inactivation and thereby disabling E2F-driven apoptosis, while allowing proliferation to occur. This model predicts that E2F and FOXO are simultaneously active in the nucleus only after certain oncogenic stresses, such as Rb1 loss.

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