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Figure 2 | Molecular Cancer

Figure 2

From: The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

Figure 2

HPV pseudovirions enter the host epithelial cells (keratinocytes) by interacting with α6β4 integrin receptor [154] or growth factor receptor [80] to enhance cell proliferation through the activation of the PI3K/Akt/mTOR and PI3k signalling pathway. Without the oncogenic roles of E6/E7E5, it is impossible for HPV pseudovirions to induce formation of cancerous cells by activating the PI3K/Akt signalling pathway.

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