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Figure 3 | Molecular Cancer

Figure 3

From: KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation

Figure 3

Klf5 deletion increases protein expression of Hif1α and pro-angiogenic factors. (A, B) IHC staining of Hif1α in mouse prostates at 4 months for Pten −/− and 12 months for Pten +/−. The numbers of Hif1α-positive cells and total prostatic epithelial cells were counted with ImageJ software for each mouse. (C, D) Protein expression of pro-angiogenic factors Vegf, Pdgf-d and Pdgf-b as detected by IHC staining with the same mouse tissues used in panels A and B. Three or 4 mice were used for each group. *, P < 0.05; **, P < 0.01; N.S., not statistically significant.

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Molecular Cancer

ISSN: 1476-4598